Research focus

The research theme is Molecular control of signaling in cancer associated with aging. To study signal transduction molecules, scientific interests are in understanding the molecular signalling machinery controlling fundamental cellular processes like cell death/survival, migration and cellular differentiation. and this project specifically added mitochondria and aging. With this in view, comprehensive analysis of these MAPK signaling will provide important insights into the molecular mechanisms involved in the development of cancer. Understand MAPK signaling, our group should be able to develop innovative therapeutic concepts that will enable us to attack tumor cell.

Research objectives

  • The RAF/MEK/ERK pathways controlled by protein kinases are involved in the initiation and progression cancer forms
  • Understanding of cancer associated with aging there should be developed new therapeutical options for tumorgenesis
  • Biomarker strategy development and implementation for oncology clinical trials

Top publications

  1. Murali A, Jaeyoung Shin, Yurugi H, Krishnan A, Akutsu M, Carpy A, Macek B, Rajalingam K. (2017) Ubiquitin-dependent regulation of Cdc42 by XIAP. Cell Death Dis. 29;8(6):e2900
  2. Jaeyoung Shin, Thomas Kubin, Marcus Krüger, Sawa Kostin, Jochen Pöling, Ulf Rapp and Thomas Braun. (2016) BRAF activates PAX3 to control muscle precursor cell migration during forelimb muscle development. eLIFE, 1;5. pii:e18351
  3. Jochen Pöling, Praveen Gajawada, Manfred Richter, Holger Lörchner, Viktoria Polyakova, Sawa Kostin, Jaeyoung Shin, Astrid Wietelmann, Thomas Böttger, Thomas Kubin and Thomas Braun. (2014) Therapeutic targeting of the oncostatin M receptor-β prevents inflammatory heart failure. Basic Res Cardiol, 109 (1):396
  4. Jaeyoung Shin, Hanjoong Jo, Heonyong Park. (2006) Caveolin-1 is transiently dephosphorylated by shear stress-activated protein tyrosine phosphatase mu. Biochemical and Biophysical Research Communications, 339:3, 737-741
  5. Jaeyoung Shin, Jongmin Kim, Byungkyu Ryu, Sung-Gil Chi and Heonyong Park. (2006) Caveolin-1 Is Associated with VCAM-1 Dependent Adhesion of Gastric Cancer Cells to Endothelial Cells. Cellular Physiology and Biochemistry, 17, 211-220

Team members

  • Dr. Jaeyoung Shin
  • Sofia Faes Morazzo

Principal Investigator

Dr. Jaeyoung Shin
Dr. Jaeyoung Shin
Principal Investigator Junior
Phone: +420 54 318 jen mobil