The Intensive Care Research group (INC) focuses on a clinical patient-oriented investigation of mechanisms of development, progression and outcome of critical illness. Cooperation with several basic research labs provides us wide opportunities for translational scientific approach by combining clinical with cellular and molecular data. Thanks to the cooperation with Cellular and Molecular Immunogerulation group, the project focusing on Immunology of sepsis has been smoothly running and bringing promissing results. One of our objectives is to test novel biomarkers of critical ilness. Therefore, we investigate several circulating substances and monocytic surface markers in prediction of patient mortality, therapeutic response and onset of complications. Secondary focus of the group is a peri-operative medicine and anestheziological management of at-risk patients.