Research focus

The Nuclear Cardiology and Cardiac CT group (NCT) is equipped by one of two cadmium-zinc-telluride SPECT cameras in the Czech Republic. The NCT focuses on new imaging protocols using cadmium-zinc-telluride technique in nuclear cardiology. The group successfully tested and published feasibility of low-dose myocardial perfusion protocol using 201-thallium. The research is currently focused on diagnostic and prognostic verification of this low-dose protocol. The group also plans to start imaging of myocardial sympathetic innervation using 123-iodine in patients with heart failure and performs multimodality imaging of myocardial viability in collaboration with Cardiovascular Magnetic Resonance group.

Research objectives

  • Development and testing low-dose imaging protocols in nuclear cardiology.
  • Improvement of imaging protocols used for assessment and quantification of myocardial ischemia.
  • Improvement of the risk stratification in patients with heart failure.

Technological equipment

  • Dedicated cardiac SPECT scanner GE Discovery NM 530c – SPECT camera equipped by solid-state cadmium-zinc-telluride semiconductor detectors, with better sensitivity and spatial resolution against classic scintillation camera.  
  • Workstation Xeleris for assessment of nuclear heart imaging.

Top publications

  • KINCL, V., VAŠKU, A., MELUZÍN, J., PANOVSKÝ, R., SEMÉNKA, J., GROCH, L. Association of the eNOS 4a/b and -786T/C Polymorphisms with coronary artery disease, obesity and diabetes mellitus. Folia Biologica; 2009; 55:187-191.
  • KAMÍNEK, M., METELKOVA, I., BUDIKOVA, M., KORANDA, P., HENZLOVA, L., HAVEL, M., SOVOVA, E., KINCL, V. Diagnosis of high-risk patients with multivessel coronary artery disease by combined cardiac gated SPET imaging and coronary calcium score. Hellenic Journal of Nuclear Medicine. 2015; 18(1), 31-34.
  • KINCL, V., MÁCHAL, J., DROZDOVÁ, A., PANOVSKÝ, R., VAŠKŮ, A. The Relation between eNOS -786 C/T, 4 a/b, MMP-13 rs640198 G/T, Eotaxin 426 C/T, -384 A/G, and 67 G/A Polymorphisms and Long-Term Outcome in Patients with Coronary Artery Disease. Disease Markers. 2015; 2015(2015), 232048.
  • KINCL, V., FEITOVÁ, V., PANOVSKÝ, R., ŠTĚPÁNOVÁ, R. Assessment of the severity of acute pulmonary embolism using CT pulmonary angiography parameters. Biomedical papers. 2015; 159(2), 259-265.
  • KINCL, V., KAMÍNEK, M., VAŠINA, J., PANOVSKÝ, R., HAVEL, M. Feasibility of ultra low-dose thallium stress-redistribution protocol including prone imaging in obese patients using CZT camera. International Journal of Cardiovascular Imaging. 2016; 32(9), 1463-1469.

Other selected results

  • The Nuclear Cardiology and Cardiac CT group has published the feasibility of ultra low-dose thallium protocol of myocardial perfusion. The administered activity was 0.5MBq per kg of body weight, which is the lowest activity described so far.

Team members

  • MUDr. Veronika Bednárová
  • prof. MUDr. Milan Kamínek, Ph.D.
  • MUDr. Vladimír Kincl, Ph.D.
  • Ing. Iva Křivánková, DiS.
  • Ing. Martin Vašek
  • MUDr. Jiří Vašina
  • Mgr. Monika Velichová

Principal Investigator

MUDr. Vladimír Kincl, Ph.D.
MUDr. Vladimír Kincl, Ph.D.
Principal Investigator Junior
Phone: +420 54 318 2409

Assistant

Lucie Knoppová
Lucie Knoppová
Research Assistant
Phone: +420 54 318 2879