Research focus

The TNA aims at furthering our understanding of aging and age-related disorders, in particular, neurodegenerative ones. TNA focuses on understanding the murky grey zone between physiological aging and preclinical and early symptomatic neurodegenerative disorders such as Alzheimer`s disease. Intriguingly, traumatic brain injury recapitulates many of the features found in aging and early symptomatic Alzheimer`s disease. Uniquely TNA takes advantage of its clinical as well as basic scientific knowledge and experience to bring further progress in its specific research field of interest. Thorough understanding of behavioral and cognitive neurology is coupled to stem cells and animal models of aging and neurodegeneration with particular attention to synaptic and axonal changes.

Research objectives

  • Identification the earliest change of aging and neurodegeneration.
  • Understanding mechanism underlying aging and neurodegeneration.
  • Generation of human stem cellsderived neuronal and glial lineages to address aging and neurodegeneration.

Main partners

  • Mayo Clinic, Rochester, MN, USA
  • University of California, San Diego, CA, USA
  • University of Buenos Aires, Buenos Aires, Argentina

Technological equipment

  • Development of a novel human stem cells based on traumatic injury model.
  • Production of antibodies to diagnostics/therapeutics of Alzheimer´s Disease.
  • AutomatedImmunochemistry Scoring System.

Offered services and expertise

  • Behavioral and cognitive testing
  • Real time in vivo imaging
  • Production of human stem cells derived neuronal and glial lineages
  • Automated immunochemistry scoring

Top publications

  • STOKIN, G.B., POPOVIĆ, M., GELPI, E., KOGOJ, A., DALMAU, J., GRAUS, F. Neuropathologicalfeaturesof anti-Dipeptidyl-Peptidase-LikeProtein-6 antibodyencephalitis. Neurology. 2015,84(4), 430-432.
  • MELLONE, M., KESTORAS, D., ANDREWS, M.R., DASSIE, E., CROWTHER, R.A., STOKIN, G.B., TINSLEY, J., HORNE, G., GOEDERT, M., TOLKOVSKY, A., SPILLANTINI, M.-G. Tau PathologyisPresentIn Vivoand DevelopsIn Vitro in Sensory NeuronsfromHuman P301S TauTransgenicMice A System forScreeningDrugsagainstTauopathies. Progressive tau pathology and axonopathyin vivoand in cultureofadult sensory neuronsexpressing P301S human tau. JournalofNeuroscience. 2013, 33(46), 18175-18189.
  • ZERR, I., KALLENBERG, K., SUMMERS, D.M., ROMERO, C., TARATUTO, A., HEINEMANN, U., BREITHAUPT, M., VARGES, D., MEISSNER, B., LADOGANA, A., SCHUUR, M., HAIK, S., COLLINS, S.J., JANSEN, G.H., STOKIN, G.B., PIMENTEL, J., HEWER, E., COLLIE, D., SMITH, P., ROBERTS, H., BRANDEL, J.P., VAN DUIJN, C., POCCHIARI, M., BEGUE, C., CRAS, P., WILL, R.G., SANCHEZ, JUAN P. UpdatedclinicaldiagnosticcriteriaforsporadicCreutzfeldt Jakob disease. Brain. 2009, 132(10), 2659-2668.
  • STOKIN, G. B. AND L. S. B. GOLDSTEIN. Axonal transport and Alzheimer's disease. Annual Review of Biochemistry. 2006, 75, 607-627.
  • STOKIN, G. B., C. LILLO, T. L. FALZONE, R. G. BRUSCH, et al. Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease. Science. 2005, 307(5713), 1282-1288.

Other selected results

  • Development of a transcriptome/proteome database to Alzheimer´s disease.
  • Generation of a novel method to development of human stem cells derived neuronal and glial lineages.
  • Designing innovative approaches to real time in vivo imaging.

Team members

  • Gorazd Stokin, Ph.D. MD
  • Pratiksha V Bhat, Ph.D. MSc
  • Victorio Devoto, Ph.D.
  • Neda Dragišić, MSc.
  • Lucie Ernstbergerová
  • Monica Feole
  • Valentina Lacovich, Ph.D.
  • Ing. Mária Nováková, Ph.D.
  • PhDr. Jan Sebastian Novotný, Ph.D.
  • Isaac Geoffrey Onyango, DrSc.
  • Ing. Monika Siekelová
  • Bc. Kateřina Texlová
  • Gretsen Velezmoro Jáuregui, MSc

Principal Investigator

Gorazd Stokin, Ph.D. MD
Gorazd Stokin, Ph.D. MD
Principal Investigator
Phone: +420 54 318 1160

Assistant

Zdena Hortvíková
Zdena Hortvíková
Executive Assistant
Phone: +420 54 318 1161