The Cellular and Molecular Immunoregulation group is determined to dissect cell signaling, which controls innate immune response. CMI develops experimental models addressing the role of hematopoietic precursors and mesenchymal stem cells in orchestrating immune response and tissue regeneration. Furthermore, CMI studies unresolved aspects of pattern recognition receptors (including Toll-like receptors) signaling pathways in peripheral blood monocytes. These signaling pathways are main sensors of infection and tissue damage and play crucial role in control of acute and chronic inflammatory disorders accompanying for example tissue regeneration or ageing processes. Better understanding of pattern recognition receptors signaling may lead to new strategies for therapeutic control of inflammatory disorders.