Research focus

The Biomedical Engineering Research Group focuses on advanced acquisition and analyses of biological signals using special custom-made technologies. The main research effort is aimed at new methods and technologies for improved diagnostics for better stratification of heart and brain diseases. The BME Research Group will also serve as a core facility able to provide high-quality technical services for researchers in a way of biological signals measurement, data storage and analysis. The BME is also able to prepare specific setup of the laboratory, technologies, recording systems, etc. needed by researchers and to provide service related to data acquisition and processing.

Research objectives

  • To research various frequency components in ECG signal and their contribution in clinical practice - spatial and temporal distribution properties in QRS complex on various frequencies using new ultra-high frequency ECG (UHF-ECG) methods and technology.
  • To analyze EEG high frequency oscillations (HFOs) and it´s meaning in physiology and pathophysiology of epileptic brain.
  • To research the EEG signal propagation – the brain connectivity in physiology and pathophysiology in epilepsy and Parkinson disease.

Main partners

  • Mayo Clinic, Rochester, MN, USA
  • Imperial College London, London, UK
  • Institute of Scientific Instruments, Brno, Czech Republic

Technological equipment

  • HiSeM Laboratories – special labs for highly sensitive biological signals measurement, equipped with Faraday cages and special acquisitions systems designed for rooms with highly clean environment (in terms of electromagnetic interference).
  • Flexible Labs - full-range laboratories equipped for cardio and neuro diagnostic methods and measurement of biological signals.

Offered services and expertise

  • Biological data acquisition, analysis and archiveservices in healthcare.
  • Clinical evaluation of new technologies planned for clinical utilization.
  • Electro-magnetically clean laboratories with shielding from low frequencies (0.1Hz) and specific multichannel acquisition system.
  • Development of new diagnostic technologies and methodologies in neurology and cardiology.

Top publications

  • TOBALDINI, E., BRUGADA, J., BENITO, B., MOLINA, I., MONTSERRAT, J., KÁRA, T., LEINVEBER, P., PORTA, A., MACEDO, P., MONTANO, N., SOMERS, V. Cardiac autonomic control in Brugada syndrome patients during sleep: The effects of sleep disordered breathing. International Journal of Cardiology. 2013, 168(4), 3267-3272.
  • PRESSMAN, G., ORBAN, M., LEINVEBER, P., PAREKH, K., SINGH, M., KÁRA, T., SOMERS, V. Effects of the mueller maneuver on functional mitral regurgitation and implications for obstructive sleep apnea. American Journal of Cardiology. 2015, 115(11), 1563-1567.
  • KUCEWICZ, M., CIMBÁLNÍK, J., MATSUMOTO, J., BRINKMANN, B., BOWER, M., VASOLI, V., ŠULC, V., MEYER, F., MARSH, W., STEAD, S., WORRELL, G. High frequency oscillations are associated with cognitive processing in human recognition memory. Brain. 2014, 137(Pt 8), 2231-44.
  • BOWER, M., STEAD, M., BOWER, R., KUCEWICZ, M., ŠULC, V., CIMBÁLNÍK, J., BRINKMANN, B., VASOLI, V., ST LOUIS, E., MEYER, F., MARSH, W., WORRELL, G. Evidence for Consolidation of Neuronal Assemblies after Seizures in Humans. Journal of Neuroscience. 2015, 35(3), 999-1010.
  • REN, L., KUCEWICZ, M., CIMBÁLNÍK, J., MATSUMOTO, J., BRINKMANN, B., HU, W., MARSH, R., MEYER, F., STEAD, M., WORRELL, G. Gamma oscillations precede interictal epileptiform spikes in the seizure onset zone. Neurology. 2015, 84(6), 602-608.

Other selected results

  • Ultra-High-Frequency ECG for early diagnosis of heart disease – the new method of processing ECG signal and apparatus for carrying out the method. New technology is suitable for very sensitive measuring. Technology and method are covered by EU PCT and by two Czech patent applications.
  • Multichannel Pulse-Wave Monitor – novel non-invasive medical device for diagnostics of the state of the vascular system. Technology is covered by utility model.

Team members

  • Ing. Pavel Leinveber
  • Mgr. Andrea Dřímalková
  • Ing. Mgr. Jan Cimbálník, Ph.D.
  • Ing. Josef Halámek, CSc.
  • Ing. Pavel Jurák, CSc.
  • Ing. Petr Klimeš, Ph.D.
  • MUDr. Jolana Lipoldová, Ph.D.
  • Ing. Pavel Macháč
  • Vladimíra Macíková
  • Ing. Magdaléna Matejková
  • MUDr. Andrej Nagy
  • doc. MUDr. Miroslav Novák, CSc.
  • Bc. Vladimír Sladký
  • Ing. Ladislav Soukup
  • Ing. et Ing. Vojtěch Trávníček
  • Ing. Martin Vašek
  • Dr. Ing. Vlastimil Vondra

Principal Investigator

Ing. Pavel Leinveber
Ing. Pavel Leinveber
Head of CF
Phone: +420 54 318 5536


Mgr. Andrea Dřímalková
Mgr. Andrea Dřímalková
Study Coordinator
Phone: +420 54 318 5532