Major research interest of Cancer Plasticity group is to understand the plasticity and heterogeneity of cancer cells and the role of tumor microenvironment in regulation of cancer progression. Cellular plasticity has been considered as a factor contributing to resistance to cancer chemotherapy and poor prognosis. At the same time, recurrence and chemoresistance of many type of cancers are believed to be strongly connected with the biology of cancer stem like cells or tumor initiating cells (CSCs/TICs) and circulating tumor cells (CTCs). There is increasing evidence that cancer plasticity induced by different stimuli is a source of CSCs/TICs/CTCs. Currently we identified in vitro and in vivo experimental models showing heterogeneity cancer cell plasticity in the term of CSC and plasticity profile. We are analyzing phenotypic characteristics of single cells or single cell-derived clones with the aim to understand better molecular mechanisms associated with cell plasticity and its role in cancer progression and generation of the cells with CSCs/TICs/CTCs-like properties.