The Genome Integrity research focuses on deciphering the intrinsic functions of homologous recombination (HR) which has a dual role in the maintenance of genome stability. First, it promotes the faithful repair of DNA double-strand breaks belonging among of the most lethal forms of DNA damage. Moreover, HR is required also for stabilizing stalled replication forks, promoting their reversal, protection and restart to ensure completion of replication and ensure genome maintenance. Inability to perform and regulate recombination is linked to human infertility, miscarriage and genetic diseases, particularly cancer further emphasizing the importance of better mechanistic understanding of this pathway. Furthermore, the GENI group focuses on the detail study of nucleases which comprise an integral part of many DNA repair pathways and their inactivation leads to genomic instability and cancer.