Research focus

AC is a research facility keen to provide knowledge, knowhow and technologies to cutting edge in vivo research. AC supports other research groups from experimental design to practical procedures, including ethical authorization steps.

AC is focused on standardization of animals housing and experimental procedures according to the European and national legislation and regulatory compliances (e.g. FDA and MHRA). We believe that good and reproducible data can be achieved only if optimal animal health and welfare are fulfilled.

Research objectives

  • Fulfilment of 3Rs Policy in in vivo research.
  • Refinement of experimental procedures with implementation of Systematic Review process.
  • Compliance of pre-clinical research with current legislation and regulatory bodies.

Main partners

  • University of Veterinary and Pharmaceutical Sciences Brno, Brno, Czech Republic
  • Vienna Biocenter Core Facilities GmbH, Vienna, Austria
  • Medical University of Vienna, Vienna, Austria
  • Institute of Molecular and Translational Medicine; Faculty of Medicine and Dentistry; Palacky University Olomouc, Olomouc, Czech Republic

Technological equipment

Equipment for large animals:

  • NIOBE Stereotaxis Magnetic Navigation System, complete with the Odyssey Cinema System
  • -1.5 T Signa NMR from GE Healthcare, completed with the set-up for anaesthesia
  • Ultrasound systems: VIVID 7 Dimension 4D Breakthrough 2008, VIVID I Breakthrough 2009
  • Cryocath Ablation System
  • Endoscopic and laparoscopic instrumentations

Equipment for rodent studies:

  • ECG TUNNEL and Non Invasive Blood Pressure System (EMKA Technologies)
  • Stellar Telemetry System for Rodents (TSE Systems)
  • Vevo 2100 Imaging System (Visualsonics)
  • Behavioural Set-up: Intellicage System, Phenomaster System, Motorater, Multiconditioning System (TSE Systems)
  • Cryostat (Nikon) and Tissue Processor (Leica TP1020)

Offered services and expertise

LAR has experience in supervising and carrying out experimental procedures on rodents and pigs models.

  • Design of experimental procedures for preclinical research with rodents and pigs.
  • Assuring the project license and authorization process.
  • Carrying out experimental procedures with imaging techniques on rodents and pigs with proper veterinarian and technicians’ assistance.
  • Compliance with regulatory framework (MHRA, EMA, FDA).

Team members

  • Marta Duchoňová
  • Mgr. Hana Jedličková
  • Mgr. Jitka Glossová
  • MVDr. Eduard Göpfert, Ph.D.
  • Ing. Klára Holíková
  • Agata Miska-Schramm, Ph.D.
  • MVDr. Iva Trojanová, Ph.D.
  • Darja Urbánková

Principal Investigator

Agata Miska-Schramm, Ph.D.
Agata Miska-Schramm, Ph.D.
Head of CF

Assistant

Mgr. Hana Jedličková
Mgr. Hana Jedličková
Assistant
Phone: +420 54 318 5434