Research focus

The Sleep Medicine Research Group plans to initiate three crucial research studies on assessing the role of sleep apnea treatment, prognosis of patients after myocardial infarction and prevention of sudden cardiac death and atrial fibrillation recurrence. Important part of the SMED activities will be continuous data analysis from projects where enrollment of patients was already completed. This way can evaluate a rising opportunity to identify a severe risk factors and to eliminate it via a corresponding therapy. The SMED Research Group would like to establish one of the first center capable of monitoring the frequency and appropriate use of technologies for SA treatment. Center of telemonitoring will be established as an integral part of the current Cardiovascular Sleep Research Center and its support will be crucially important to improve the reliability of outcomes of above described sleep research studies.

Research objectives

  • Characterize the role of sleep apnea and its treatment in myocardial infarction, heart failure, sudden cardiac death and atrial fibrillation.
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  • Elucidate pathophysiological mechanisms underlying sleep apnea.
  • Evaluate relationship between sleep apnea and metabolic disorders.

Main partners

  • The Charité - Universitätsmedizin Berlin, Berlin, Germany
  • The University of Milan, Milan, Italy
  • Mayo Clinic, Rochester, MN, USA

Technological equipment

  • Polysomnography acquisition system (PSG) Grael and Siesta – full polysomnography.
  • Embletta MPR PG sys XS - polygraphy.
  • ResMed AirCurve 10 CS PaceWave - noninvasive ventilation.
  • ResMed AirSense 10 AutoSet - noninvasive ventilation.
  • ResMed S9 ST - noninvasive ventilation.
  • Vivid q - echocardiography.

Offered services and expertise

  • Fully functional Sleep lab certified by Czech Sleep Research and Sleep Medicine Society and also certified as research center by European Sleep Research Society.
  • Polygraphy and manual or automatic titration of positive airway pressure therapy (CPAP, BiPAP, ASV, AVAPS etc.).
  • Full polysomnography.

Top publications

  • KONEČNÝ, T., GESKE, J., LUDKA, O., ORBAN, M., BRADY, P., ABUDIAB, M., ALBUQUERQUE, F., PLACEK, A., KÁRA, T., SAHAKYAN, K., GERSH, B., TAJIK, A., ALLISON, T., OMMEN, S., SOMERS, V. Decreased Exercise Capacity and Sleep Disordered Breathing in Patients with Hypertrophic Cardiomyopathy. Chest. 2015, 147(6), 1574-1581.
  • LUDKA, O., ŠTĚPÁNOVÁ, R., VYSKOČILOVÁ, M., GALKOVÁ, L., MIKOLÁŠKOVÁ, M., BĚLEHRAD, M., KOŠŤÁLOVÁ, J., MIHALOVÁ, Z., DROZDOVÁ, A., HLÁSENSKÝ, J., GACIK, M., PUDILOVÁ, l., MIKUŠOVÁ, T., FISCHEROVÁ, B., SERT-KUNIYOSHI, F., SOMERS, V., ŠPINAR, J., KÁRA, T. Sleep apnea prevalence in acute myocardial infarction - The Sleep Apnea in Post-acute Myocardial Infarction Patients (SAPAMI) Study. International Journal of Cardiology. 2014, 176(1), 13-19.
  • KONEČNÝ, T., SOMERS, V. Sleep-Disordered Breathing in Hypertrophic Cardiomyopathy: Challenges and Opportunities. Chest. 2014, 146(1), 228-34.
  • ČUNDRLE, I., SOMERS, V., JOHNSON, B., SCOTT, C., OLSON, L. Exercise End-Tidal Carbon Dioxide Predicts Central Sleep Apnea in Heart Failure Patients. Chest. 2015, 147(6), 1566-1573.
  • ČUNDRLE, I., SOMERS, V., SINGH, P., JOHNSON, B., SCOTT, C., VAN DER WALT, C., OLSON, L. Leptin Deficiency Promotes Central Sleep Apnea in Patients With Heart Failure. Chest. 2014, 145(1), 72-78.

Other selected results

This research group detected a high prevalence of previously undiagnosed SA in acute myocardial infarction patients. In this population, peak occurrence of MI onset was between 6 AM and noon in SA patients, similar to what is observed in the general population. Considering that this is a group at high risk for heart failure, fatal arrhythmia, recurrent MI and sudden death, treatment of SA may provide an important strategy for secondary prevention. Whether treating SA reduces post-MI morbidity and mortality awaits the findings of randomized controlled trials.

Team members

  • prof. MUDr. Ondřej Ludka, Ph.D.
  • Libuše Martináková, MBA
  • Mgr. Alica Červáková
  • doc. MUDr. Ivan Čundrle, Ph.D.
  • Mgr. Pavla Kobylková
  • Sylva Maršíková
  • Ivana Martenková, DiS.
  • Lenka Pavelcová
  • Lenka Piňosová, DiS.
  • prof. MUDr. Miroslav Souček, CSc.
  • Ing. Ladislav Soukup
  • Bc. Pavla Štěpánková
  • Ing. Martin Vašek
  • MUDr. Lujza Zikmund Galková

Principal Investigator

prof. MUDr. Ondřej Ludka, Ph.D.
prof. MUDr. Ondřej Ludka, Ph.D.
Principal Investigator
Phone: +420 54 318 4074

Assistant

Libuše Martináková, MBA
Libuše Martináková, MBA
Senior Study Coordinator
Phone: +420 54 318 5492