Research focus

The Acute Coronary Syndrome Research Group belongs among pioneers of primary percutaneous coronary intervention program in the Czech Republic and among one of the largest centers. The main activity of the ACS Research Group is interventional cardiology, treatment of coronary artery disease by percutaneous coronary interventions and treatment of acute coronary syndromes. The main research is focused on a new stent and scaffolds development, treatment of ST-Elevation Myocardial Infarction (STEMI) patients with multivessel disease, antiaggregation therapy after acute coronary syndromes, Tako-tsubo Cardiomyopathy, new imaging methods of coronary arteries and atherosclerotic plaque progression.

Research objectives

  • Evaluate unstable coronary plaques by optical coherence tomography and near infrared spectroscopy.
  • Test newly developed coronary stents and scaffolds in animal models and humans.
  • Testing the role of genetic polymorphisms on pharmacokinetics of antiplatelet drugs used for acute coronary syndromes treatment.

Technological equipment

  • Angiography System - Digital Subtraction Angiography (DSA)
  • Optical Coherence Tomography (OCT)
  • Near Infrared Spectroscopy (NIRS)
  • Intracoronary Ultrasound (IVUS)
  • Single-Photon Emission Computed Tomography (SPECT)

Top publications

  • UTHAMARAJ, S., TEFFT, B., HLINOMAZ, O., SANDHU, G., DRAGOMIR-DAESCU, D. Ferromagnetic Bare Metal Stent for Endothelial Cell Capture and Retention. Jove-Journal of Visualized Experiments. 2015, SEP(103), e53100.
  • UTHAMARAJ, S., TEFFT, B., KLABUSAY, M., HLINOMAZ, O., SANDHU, G., DRAGOMIR-DAESCU, D. Design and Validation of a Novel Ferromagnetic Bare Metal Stent Capable of Capturing and Retaining Endothelial Cells. Annals of Biomedical Engineering. 2014, 42(12), 2416-2424.
  • MÁCHAL, J., PÁVKOVÁ-GOLDBERGOVÁ, M., HLINOMAZ, O., GROCH, L., VAŠKŮ, A. Patients with chronic three-vessel disease in a 15-year follow-up study: genetic and non-genetic predictors of survival. Medicine. 2014, 93(28), e278.
  • PLEVA, L., KUKLA, P., KUSNIEROVA, P., ZAPLETALOVA, J., HLINOMAZ, O. Comparison of the Efficacy of Paclitaxel-Eluting Balloon Catheters and Everolimus-Eluting Stents in the Treatment of Coronary In-Stent Restenosis The Treatment of In-Stent Restenosis Study. Circulation-Cardiovascular Interventions. 2016, 9(4), e003316.
  • KINCL, V., MÁCHAL, J., DROZDOVÁ, A., PANOVSKÝ, R., VAŠKŮ, A. The Relation between eNOS -786 C/T, 4 a/b, MMP-13 rs640198 G/T, Eotaxin 426 C/T, -384 A/G, and 67 G/A Polymorphisms and Long-Term Outcome in Patients with Coronary Artery Disease. Disease Markers. 2015, 2015(2015), 232048.

Other selected results

  • Novel Ferromagnetic Bare Metal Stent Capable of Capturing and Retaining Endothelial Cells – New type of stent for Rapid healing of vascular system reducing complications associated with stent thrombosis, restenosis, and bleeding related to antiplatelet drugs.

  • Novel Ferromagnetic Stent Graft – New type ofstent graft with small diameter (3 mm) - magnetic stent graft of rapid endothelialization represents a new therapeutic approach in peripheral and coronary arteries, thereby reducing the need for prolonged anticoagulation and antiplatelet therapy. 

Team members

  • MUDr. Ota Hlinomaz, CSc.
  • Lucie Knoppová
  • Bc. Markéta Beranová
  • MUDr. Ladislav Groch, Ph.D.
  • PhDr. Petra Kramáriková, Ph.D.
  • MUDr. Jan Máchal, Ph.D.
  • MUDr. Michal Rezek
  • MUDr. Jiří Seménka
  • MUDr. Jan Sitar
  • Ing. Martin Vašek

Principal Investigator

MUDr. Ota Hlinomaz, CSc.
MUDr. Ota Hlinomaz, CSc.
Principal Investigator
Phone: +420 54 318 5470

Assistant

Lucie Knoppová
Lucie Knoppová
Research Assistant
Phone: +420 54 318 2879