Research focus

Research activities of Stroke Research Group include development and implementation of innovative methods for the evaluation, treatment, and prevention of acute ischemic stroke. Research portfolio is designed vertically across the spectrum from basic science to clinical research and networking. The emphasis is on a translational approach so that knowledge gained through basic research is applied and tested in clinical practice to benefit patients and improve outcome after stroke. The final outcome of the research is to reduce the burden of stroke, and to improve patients' functional capacity and to achieve a better quality of life after stroke.

Research objectives

  • Research on implementation of evidence-based treatments.
  • Identification of better stroke awareness methods including program on stroke awareness in children.
  • Development of in vitro and animal model for stroke to test new diagnostics (e.g. basic thrombus imaging) and therapeutic strategies (e.g. new recanalization methods).

Main partners

  • University of Calgary, Calgary, AB, Canada
  • Karolinska University Hospital, Stockholm, Sweden
  • Columbia University Medical Center, New York, NY, USA

Technological equipment

Fully equipped Stroke Unit with neuroimaging machines:

  • Biplane angiography system, CT scanner, MRI scanner, Ultrasound machines (extracranial and transcranial diagnostics of arterial disease), X-ray devices with direct digitalization.

Rehabilitation facilities:

  • Integrated robotic system for walking, robotic systems to activate postural and locomotor mechanisms, ultrasonic and magnet therapy units, multifunctional baths, vertical beds and inclined planes.

Offered services and expertise

  • Stroke Research Network – connect with other institutions in the Czech Republic as well as in countries in Central and Eastern Europe.
  • System Engineering/Software Developing and data management -extensive background in developing, deploying, and supporting high performance computing systems for both research and commercial organizations (high performance computing, Big Data management, information security and quantum computing).
  • Diagnosis of cerebrovascular disease based in particular on multimodal imaging -acute stroke imaging including computed tomography (CT), CT angiography (multiphase CTA), CT perfusion (implementation of software RAPID, Stanford University) and magnetic resonance imaging (MRI).
  • Improved neuro-rehabilitation after stroke -research early verticalization and locomotion, hand rehabilitation, orofacial rehabilitation, robotic rehabilitation.
  • Preclinical research (animal models) -Certificate of Professional Competence Soft Tissue Surgery, thoracotomy, laparotomy.

Top publications

  • MIKULÍK, R., KADLECOVÁ, P., CZLONKOWSKA, A., KOBAYASHI, A., BROZMAN, M., SVIGELJ, V., CSIBA, L. Factors Influencing In-Hospital Delay in Treatment With Intravenous Thrombolysis. Stroke. 2012, 43(6), 1578-1583.
  • AHMED, N., WAHLGREN, N., GROND, M., HENNERICI, M., LEES, K., MIKULÍK, R., PARSONS, M., ROINE, R., TONI, D., RINGLEB, P. Implementation and outcome of thrombolysis with alteplase 3-4.5 h after an acute stroke: an updated analysis from SITS-ISTR. Lancet Neurology. 2010, 9(9), 1-10.
  • MIKULÍK, R., GOLDEMUND, D., REIF, M., AULICKÝ, P., KRUPA, P. Outcome of patients with negative CT angiography results for arterial occlusion treated with intravenous thrombolysis. Stroke. 2009, 40(3), 1-6.
  • MIKULÍK, R., BUNT, L., HRDLIČKA, D., DUŠEK, L., VÁCLAVÍK, D., KRÝZA, J. Calling 911 in response to stroke: a nationwide study assessing definitive individual behavior. Stroke. 2008, 39(6), 1844-1849.
  • MIKULIK, R., RIBO, M., HILL, M.D., GROTTA, J.C., MALKOFF, M., MOLINA, C.A., RUBIERA, M., DELGADO-MEDEROS, R., ALEXANDROV, A.V. The accuracy of serial NIH stroke scale scores to identify artery status in acute ischemic stroke Circulation. 2007, 115, 2660-2665.

Other selected results

  • The Stroke Research Group has developed platforms for collection of imaging data and stroke care quality data.
  • Omnidirectional wheel with feedback elements and the brake disc - patent application.

Team members

  • prof. MUDr. Robert Mikulík, Ph.D.
  • Mgr. Martina Slachová
  • Mgr. Tereza Báťková
  • Mgr. Jan Bobek, Ph.D.
  • Alexandra Brabcová, DiS.
  • Olga Cherepkova, MSc
  • MUDr. Petra Cimflová
  • Trung Ngoc Dao
  • MVDr. Jana Doležalová, Ph.D.
  • Adéla Dvorská
  • Andreea-Madalina Grecu, MSc.
  • MUDr. Michal Haršány, Ph.D.
  • doc. MUDr. Aleš Hejčl, Ph.D.
  • Ing. Sabina Hladíková
  • MVDr. Jana Hložková, Ph.D.
  • Olga Kratochvílová
  • Ing. Hana Maršálková
  • Bc. Dominika Pirklová
  • Ing. Pavla Šafránková, DiS.
  • MVDr. Peter Scheer, Ph.D.
  • MUDr. Ing. Mgr. Petra Šedová, Ph.D.
  • Ing. Jakub Šimkovič
  • Bc. Steven Simsic
  • Mgr. Martina Sittová, Ph.D.
  • Ing. MgA. Veronika Svobodová
  • Mgr. Sandra Thalerová
  • Mgr. Miroslav Vařecha, Ph.D.
  • Ing. Martin Vašek
  • Bc. Ekaterina Volevach
  • MUDr. Ondřej Volný, Ph.D.
  • Kristýna Znamenáčková

Principal Investigator

prof. MUDr. Robert Mikulík, Ph.D.
prof. MUDr. Robert Mikulík, Ph.D.
Principal Investigator
Phone: +420 54 318 4080