Research focus

Research actvites of the Stroke Research Group (STR) include development and implementation of innovative methods for the evaluation, treatment, and prevention of acute ischemic stroke. Research portfolio is designed across translational axis from basic science to clinical research and implementation research. The emphasis is on a translational approach so that knowledge gained through basic research is applied and tested in clinical practice and then translated into health care system and population.

Research objectives

  • Research on implementation of evidence-based treatments.
  • Development of in vitro and animal model for stroke to test new diagnostics (e.g. basic thrombus imaging) and therapeutic strategies (e.g. new recanalizaton methods).
  • Identification of beter stroke awareness methods including program on stroke awareness in children.

Main partners

  • European Stroke Organisation, Switzerland
  • ANGELS Initative, The world-wide stroke support project, Germany
  • University of Calgary, Canada
  • Network of Stroke Centres in Central and Eastern Europe

Technological equipment

Fully equipped Stroke Unit with neuroimaging machines.

The Laboratory of Nanopharmacology NAPHARM is a joint workplace of the Veterinary Research Institute and FNUSA-ICR.

IT infrastructure for medical databases and research.

Offered services and expertise

Simulation training and methodology- is intended for stroke teams and professionals in stroke.

System Engineering/Software Developing and data management.

Preclinical Research: highly sophisticated in vitro flow models and small animal models of stroke.

Web-based platform for education of children and lay public in Stroke.

Coordination of clinical trials.

Top publications

  1. HART, R., SHARMA, M., MUNDL, H., KASNER, S., BANGDIWALA, S., BERKOWITZ, S., SWAMINATHAN, B., LAVADOS, P., WANG, Y., WANG, Y., DAVALOS, A., SHAMALOV, N., MIKULÍK, R. et al. Rivaroxaban for Stroke Prevention after Embolic Stroke of Undetermined Source. New England Journal of Medicine. 2018, 378(23), 2191-2201. ISSN 0028-4793. IF 70.670.
  2. MENON, B., AL-AJLAN, F., NAJM, M., PUIG, J., CASTELLANOS, M., DOWLATSHAHI, D., CALLEJA, A., SOHN, S., AHN, S., POPPE, A., MIKULÍK, R. et al. Association of Clinical, Imaging, and Thrombus Characteristics with Recanalization of Visible Intracranial Occlusion in Patients with Acute Ischemic Stroke. JAMA. 2018, 320(10), 1017-1026. ISSN 0098-7484. IF 51.273.
  3. ALEXANDROV, AV., KOHRMANN, M., SOINNE, L., TSIVGOULIS, G., BARRETO, AD., DEMCHUK, AM., SHARMA, VK., MIKULÍK, R. et al. Safety and efficacy of sonothrombolysis for acute ischaemic stroke: a multicentre, double-blind, phase 3, randomised controlled trial. Lancet Neurology. 2019, 18(4), 338-347. ISSN 1474-4422. IF 28.755.
  4. Mikulík R, Eckstein J, Pearce LA, Mundl H, Rudilosso S, Olavarría VV, Shoamanesh A, Chamorro Á, Martí-Fàbregas J, Veltkamp R, Öztürk Ş, Tatlisumak T, Peacock WF, Berkowitz SD, Connolly SJ, Hart RG. Frequency and Predictors of Major Bleeding in Patients With Embolic Strokes of Undetermined Source: NAVIGATE-ESUS Trial. Stroke 2020, July; 51:2139–2147. 

Other selected results

The Stroke Research Group has developed innovative platorms for evaluating stroke care quality data (RES-Q), as well as for providing education and testing to school children about stroke (HOBIT). Currently, an advanced medical imaging database for stroke, as well as other registry based research initatives.

Highly sophisticated in vitro 3D flow models for testing new recanalization methods.

Contact persons

  • prof. MUDr. Robert Mikulík, Ph.D.
  • Ing. Marie Klimešová, Ph.D.
  • Mgr. Martina Slachová
  • Ing. Paul Mark Mensah Ablorh
  • Mgr. Tereza Báťková
  • Mgr. Jan Bobek, Ph.D.
  • Alexandra Brabcová, DiS.
  • Trung Ngoc Dao
  • MVDr. Jana Doležalová, Ph.D.
  • Mgr. Marcela Ely, Ph.D.
  • MUDr. Michal Haršány, Ph.D.
  • doc. MUDr. Aleš Hejčl, Ph.D.
  • Ing. Sabina Hladíková
  • MVDr. Jana Hložková, Ph.D.
  • Olga Kratochvílová
  • Ing. Hana Maršálková
  • Ing. Václav Pasáček
  • Bc. Dominika Pirklová
  • Bc. Martina Pospíchalová
  • Ing. Pavla Šafránková, DiS.
  • MVDr. Peter Scheer, Ph.D.
  • MUDr. Ing. Mgr. Petra Šedová, Ph.D.
  • Ing. Jakub Šimkovič
  • Ing. MgA. Veronika Svobodová
  • Mgr. Sandra Thalerová
  • Mgr. Miroslav Vařecha, Ph.D.
  • Ing. Martin Vašek
  • Bc. Ekaterina Volevach
  • MUDr. Ondřej Volný, Ph.D.
  • Kristýna Znamenáčková

Principal Investigator

prof. MUDr. Robert Mikulík, Ph.D.
prof. MUDr. Robert Mikulík, Ph.D.
Principal Investigator
Phone: +420 54 318 4080